It is the combination of steps one and two that gives rise to the major circulating metabolites 13, 14-dihydro-15-ketoprostaglandins, which are measured by radioimmunoassay RIA.
Am J Obstet Gynecol 172: 77, 1995 Mayer RJ, Marshall LA: New insights on mammalian phospholipase A 2 s : Comparison of arachidonyl selective and nonselective enzymes.
Second, prostaglandins can increase uterine tone or contractile activity, resulting in a significant reduction in uterine blood flow by mechanical compression of the uterine vasculature.
A well-oriented warden now takes special care of these girls, providing them information about menstruation and other reproductive health related issues.