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Although surgical resection is still the optimal treatment option for early-stage hepatocellular carcinoma HCC in patients with well compensated cirrhosis, thermal ablation techniques provide a valid non-surgical treatment alternative, thanks to their minimal invasiveness, excellent tolerability and safety profile, proven efficacy in local disease control, virtually unlimited repeatability and cost-effectiveness.

PMID: 33462682 Free PMC article.

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Time-lapse of ultrasound-guided percutaneous microwave ablation of medium-sized hepatocellular carcinoma of the right lobe.

Hendriks P, Berkhout WEM, Kaanen CI, Sluijter JH, Visser IJ, van den Dobbelsteen JJ, de Geus-Oei LF, Webb AG, Burgmans MC.

Different energy sources are currently employed in clinics as physical agents for percutaneous or intra-surgical thermal ablation of HCC nodules.

In this review we provide an extensive and detailed overview of the key physical and technical aspects of MWA and of the currently available systems, and we want to discuss the most relevant published data on MWA treatments of HCC nodules in regard to clinical results and to the type and rate of complications, both in absolute terms and in comparison with RFA.

MWA, first introduced in the Far Eastern clinical practice in the 80s', showing promising results but also severe limitations in the controllability of the emitted field and in the high amount of power employed for the ablation of large tumors, resulting in a poor coagulative performance and a relatively high complication rate, nowadays shows better results both in terms of treatment controllability and of overall coagulative performance, thanks to the improvement of technology.

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